Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice.

Insulin-like growth factor binding protein-2 (IGFBP-2) stimulates osteoblast differentiation but only male Igfbp2 null mice have a skeletal phenotype. The trophic actions of IGFBP-2 in bone are mediated through its binding to receptor tyrosine phosphatase beta (RPTPβ). Another important ligand for RPTPβ is pleiotrophin (PTN), which also stimulates osteoblast differentiation. We determined the change in PTN and RPTPβ in Igfbp2-/- mice. Analysis of whole bone mRNA in wild-type and knockout mice revealed increased expression of Ptn. Rptpβ increased in gene-deleted animals with females having greater expression than males. Knockdown of PTN expression in osteoblasts in vitro inhibited differentiation, and addition of PTN to the incubation medium rescued the response. Estradiol stimulated PTN secretion and PTN knockdown blocked estradiol-stimulated differentiation. PTN addition to IGFBP-2 silenced osteoblast stimulated differentiation, and an anti-fibronectin-3 antibody, which inhibits PTN binding to RPTPβ, inhibited this response. Estrogen stimulated PTN secretion and downstream signaling in the IGFBP-2 silenced osteoblasts and these effects were inhibited with anti-fibronectin-3. Administration of estrogen to wild-type and Igfbp2-/- male mice stimulated an increase in both areal bone mineral density and trabecular bone volume fraction but the increase was significantly greater in the Igfbp2-/- animals. Estrogen also stimulated RPTPβ expression in the null mice. We conclude that loss of IGFBP-2 expression is accompanied by upregulation of PTN and RPTPβ expression in osteoblasts, that the degree of increase is greater in females due to estrogen secretion, and that this compensatory change may account for some component of the maintenance of normal bone mass in female mice.

Bovine C Reactive Protein (CRP) ELISA Kit
DLR-CRP-b-96T	DL Develop	96T	EUR 715
Should the Bovine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ch-48T	DL Develop	48T	EUR 508
Should the Chicken C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Chicken C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ch-96T	DL Develop	96T	EUR 661
Should the Chicken C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Human C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Hu-48T	DL Develop	48T	EUR 385
Should the Human C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, urine, cerebrospinal fluid, cell culture supernates or other biological fluids.

Human C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Hu-96T	DL Develop	96T	EUR 492
Should the Human C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, urine, cerebrospinal fluid, cell culture supernates or other biological fluids.

Mouse C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Mu-48T	DL Develop	48T	EUR 489
Should the Mouse C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Mu-96T	DL Develop	96T	EUR 635
Should the Mouse C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine C Reactive Protein (CRP) ELISA Kit
DLR-CRP-p-48T	DL Develop	48T	EUR 547
Should the Porcine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine C Reactive Protein (CRP) ELISA Kit
DLR-CRP-p-96T	DL Develop	96T	EUR 715
Should the Porcine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ra-48T	DL Develop	48T	EUR 426
Should the Rat C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ra-96T	DL Develop	96T	EUR 549
Should the Rat C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Rb-48T	DL Develop	48T	EUR 508
Should the Rabbit C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Rabbit C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Rb-96T	DL Develop	96T	EUR 661
Should the Rabbit C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Bovine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-b-48Tests	Reddot Biotech	48 Tests	EUR 580

Bovine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-b-96Tests	Reddot Biotech	96 Tests	EUR 807

Chicken C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ch-48Tests	Reddot Biotech	48 Tests	EUR 534

Chicken C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ch-96Tests	Reddot Biotech	96 Tests	EUR 742

Human C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Hu-48Tests	Reddot Biotech	48 Tests	EUR 388

Human C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Hu-96Tests	Reddot Biotech	96 Tests	EUR 533

Mouse C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511

Mouse C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709

Porcine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-p-48Tests	Reddot Biotech	48 Tests	EUR 580

Porcine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-p-96Tests	Reddot Biotech	96 Tests	EUR 807

Rat C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ra-48Tests	Reddot Biotech	48 Tests	EUR 437

Rat C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ra-96Tests	Reddot Biotech	96 Tests	EUR 603

Rabbit C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Rb-48Tests	Reddot Biotech	48 Tests	EUR 534

Rabbit C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Rb-96Tests	Reddot Biotech	96 Tests	EUR 742

Bovine C Reactive Protein (CRP) ELISA Kit
RD-CRP-b-48Tests	Reddot Biotech	48 Tests	EUR 555

Bovine C Reactive Protein (CRP) ELISA Kit
RD-CRP-b-96Tests	Reddot Biotech	96 Tests	EUR 771

Chicken C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ch-48Tests	Reddot Biotech	48 Tests	EUR 511

Chicken C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ch-96Tests	Reddot Biotech	96 Tests	EUR 709

Human C Reactive Protein (CRP) ELISA Kit
RD-CRP-Hu-48Tests	Reddot Biotech	48 Tests	EUR 372

Human C Reactive Protein (CRP) ELISA Kit
RD-CRP-Hu-96Tests	Reddot Biotech	96 Tests	EUR 510

Mouse C Reactive Protein (CRP) ELISA Kit
RD-CRP-Mu-48Tests	Reddot Biotech	48 Tests	EUR 489

Mouse C Reactive Protein (CRP) ELISA Kit
RD-CRP-Mu-96Tests	Reddot Biotech	96 Tests	EUR 677

Porcine C Reactive Protein (CRP) ELISA Kit
RD-CRP-p-48Tests	Reddot Biotech	48 Tests	EUR 555

Porcine C Reactive Protein (CRP) ELISA Kit
RD-CRP-p-96Tests	Reddot Biotech	96 Tests	EUR 771

Rat C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ra-48Tests	Reddot Biotech	48 Tests	EUR 419

Rat C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ra-96Tests	Reddot Biotech	96 Tests	EUR 577

Rabbit C Reactive Protein (CRP) ELISA Kit
RD-CRP-Rb-48Tests	Reddot Biotech	48 Tests	EUR 511

Rabbit C Reactive Protein (CRP) ELISA Kit
RD-CRP-Rb-96Tests	Reddot Biotech	96 Tests	EUR 709

Guinea pig C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Gu-48T	DL Develop	48T	EUR 527
Should the Guinea pig C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Guinea pig C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Gu-96T	DL Develop	96T	EUR 688
Should the Guinea pig C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Guinea pig C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Gu-48Tests	Reddot Biotech	48 Tests	EUR 557

Guinea pig C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Gu-96Tests	Reddot Biotech	96 Tests	EUR 774

Guinea pig C Reactive Protein (CRP) ELISA Kit
RD-CRP-Gu-48Tests	Reddot Biotech	48 Tests	EUR 533

Guinea pig C Reactive Protein (CRP) ELISA Kit
RD-CRP-Gu-96Tests	Reddot Biotech	96 Tests	EUR 740

TruStrip RDT Dog C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-D10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Human C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-H10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Human C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack
CRP-RDT-H25	Alpha Diagnostics	1 pack	EUR 293

TruStrip RDT Monkey C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-M10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Monkey C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack
CRP-RDT-M25	Alpha Diagnostics	1 pack	EUR 293

TruStrip RDT Rat C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-R10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Rat C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack
CRP-RDT-R25	Alpha Diagnostics	1 pack	EUR 293

IL-4 Interleukin 4 Human Recombinant Protein, Yeast
PROTP05112-4	BosterBio	Regular: 10ug	EUR 317
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques.

Individual Reaction Mix 4
G065-4	ABM	200 reactions	EUR 167

pLenti-CLDN1 shRNA-4 Plasmid
PVTBAV04867-4	Lifescience Market	2 ug	EUR 356

Feline IL-4 Recombinant Protein
R00230-4	BosterBio	5ug/vial	EUR 259
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

DIGITAL SHAKER FOR 4 MICROPLATES, 120V
6780-4	CORNING	1/pk	EUR 798
Description: Lab Equipment; Shakers & Mixers

Mouse FibrOut 4, for brain, neural
4-20507	CHI Scientific	1 ml	Ask for price

Mouse FibrOut 4, for brain, neural
4-20508	CHI Scientific	5 x 1 ml	Ask for price

Rat FibrOut 4, for brain, neural
4-20533	CHI Scientific	1 ml	Ask for price

Rat FibrOut 4, for brain, neural
4-20534	CHI Scientific	5 x 1 ml	Ask for price

Human FibrOut 4, for brain, neural
4-21552	CHI Scientific	1 ml	Ask for price

Human FibrOut 4, for brain, neural
4-21553	CHI Scientific	5 x 1 ml	Ask for price

Recombinant Human 4-1BB Receptor Protein
PROTQ07011-4	BosterBio	20ug	EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein
PROTP02776-4	BosterBio	20ug	EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

CRP/ Rat CRP ELISA Kit
ELA-E0829r	Lifescience Market	96 Tests	EUR 886

Crp/ Rat Crp ELISA Kit
ELI-02799r	Lifescience Market	96 Tests	EUR 886

Canine CRP(CRP) ELISA Kit
QY-E70170	Qayee Biotechnology	96T	EUR 426

Bone Dissociation System 4 (Osteoblasts), Adult Mouse
4-20214	CHI Scientific	ea	Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat
4-20304	CHI Scientific	ea	Ask for price

Pituitary Dissociation System 4 (Pituitary), Adult mouse
4-20404	CHI Scientific	ea	Ask for price

Thymus Dissociation System 4 (Epithelial), Adult rat
4-20444	CHI Scientific	ea	Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG
6781-4	CORNING	1/pk	EUR 798
Description: Lab Equipment; Shakers & Mixers

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-UK PLUG
6782-4	CORNING	1/pk	EUR 798
Description: Lab Equipment; Shakers & Mixers

Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat
4-20234	CHI Scientific	ea	Ask for price

Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse
4-20324	CHI Scientific	ea	Ask for price

Pancreas Dissociation System 4 (Islets), Mouse and Rat
4-20374	CHI Scientific	ea	Ask for price

Skin Dissociation System 4 (Keratinocytes), Mouse and Rat
4-20434	CHI Scientific	ea	Ask for price

CRP protein
30C-CP1000U	Fitzgerald	1 mg	EUR 349
Description: Purified native Human CRP protein

CRP protein
30R-2081	Fitzgerald	100 ug	EUR 322
Description: Recombinant human CRP protein

CRP protein
30R-2389	Fitzgerald	250 ug	EUR 152
Description: Purified recombinant Human CRP protein

CRP protein
30R-2740	Fitzgerald	10 ug	EUR 341
Description: Purified recombinant Human CRP protein

CRP protein
30R-2984	Fitzgerald	1 mg	EUR 380
Description: Purified recombinant Human CRP protein

CRP Protein
30R-3412	Fitzgerald	1 mg	EUR 300
Description: Human C-reactive protein

CRP protein
30R-AC001x	Fitzgerald	10 mg	EUR 457
Description: Highly purifed Human CRP protein

CRP protein
30R-AC067	Fitzgerald	1 mg	EUR 448
Description: Purified native Human CRP protein

CRP protein
30-1092	Fitzgerald	1 mg	EUR 393
Description: Purified recombinant Human CRP protein

CRP protein
30-1094	Fitzgerald	100 ug	EUR 155
Description: Purified native Human CRP protein

CRP protein
30-1906	Fitzgerald	1 mg	EUR 336
Description: Native human CRP protein

CRP protein
30-AC05	Fitzgerald	5 mg	EUR 277
Description: Highly purified Human CRP protein

CRP protein
30-AC07	Fitzgerald	5 mg	EUR 1029
Description: Purified Recombinant CRP protein

CRP protein
30-AC10	Fitzgerald	5 mg	EUR 250
Description: Partially purified Human CRP protein

CRP antibody
20C-CR2015S	Fitzgerald	1 ml	EUR 133
Description: Sheep polyclonal CRP antibody

CRP antibody
20C-CR2015SP	Fitzgerald	1 ml	EUR 177
Description: Sheep polyclonal CRP antibody

CRP Antibody
31062-100ul	SAB	100ul	EUR 252

CRP Antibody
31062-50ul	SAB	50ul	EUR 187