Phytoestrogens protect joints in collagen induced arthritis by increasing IgG glycosylation and reducing osteoclast activation.

Based on previous studies, we know that estrogen can protect the joints from arthritis development by increasing IgG glycosylation and inhibiting osteoclast activation. Phytoestrogens, especially genistein and daidzein, are structurally similar to estradiol that can bind to estrogen receptors (ERs). However, how phytoestrogens affect IgG glycosylation and osteoclast activation in vivo are not investigated so far. In this study, we used 20 mg/kg genistein or daidzein to gavage the female DBA1/J mice in collagen induced arthritis (CIA). We assessed arthritis and bone erosion by clinical scores, histopathology, and micro-CT analysis. Inflammatory cells such as neutrophils, B cells, macrophages and T cells in the peripheral blood were analyzed by flow cytometry. Phagocytic function of peritoneal macrophages was assessed by using FITC-labeled Escherichia coli. New monoclonal antibodies against CII were produced, purified and analyzed. Glycosylation levels of polyclonal and monoclonal IgG were detected by lectin-ELISA. Quantitative PCR was used to analyze the genes related to IgG glycosylation (B4galt1, St6gal1) and osteoclasts (TRAP, NFATC1, c-Fos). Expression of NF-κB and Akt signaling pathways as well as downstream transcription factors NFATc1 and c-Fos was studied by Western blot. Our results show that phytoestrogens protect mice from CIA by increasing IgG glycosylation leading to amelioration of inflammation and inhibiting the NF-κB pathway and NFATc1/c-Fos to decrease the activity of osteoclasts. In conclusion, phytoestrogens can protect bone and joints in CIA mice by increasing IgG glycosylation and inhibiting osteoclast activity.

Bovine C Reactive Protein (CRP) ELISA Kit

DLR-CRP-b-96T 96T
EUR 715
  • Should the Bovine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Ch-48T 48T
EUR 508
  • Should the Chicken C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Chicken C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Ch-96T 96T
EUR 661
  • Should the Chicken C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Human C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Hu-48T 48T
EUR 385
  • Should the Human C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, urine, cerebrospinal fluid, cell culture supernates or other biological fluids.

Human C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Hu-96T 96T
EUR 492
  • Should the Human C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, urine, cerebrospinal fluid, cell culture supernates or other biological fluids.

Mouse C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Mu-48T 48T
EUR 489
  • Should the Mouse C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Mu-96T 96T
EUR 635
  • Should the Mouse C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine C Reactive Protein (CRP) ELISA Kit

DLR-CRP-p-48T 48T
EUR 547
  • Should the Porcine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine C Reactive Protein (CRP) ELISA Kit

DLR-CRP-p-96T 96T
EUR 715
  • Should the Porcine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Ra-48T 48T
EUR 426
  • Should the Rat C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Ra-96T 96T
EUR 549
  • Should the Rat C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Rb-48T 48T
EUR 508
  • Should the Rabbit C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Rabbit C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Rb-96T 96T
EUR 661
  • Should the Rabbit C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Bovine C Reactive Protein (CRP) ELISA Kit

RDR-CRP-b-48Tests 48 Tests
EUR 580

Bovine C Reactive Protein (CRP) ELISA Kit

RDR-CRP-b-96Tests 96 Tests
EUR 807

Chicken C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Ch-48Tests 48 Tests
EUR 534

Chicken C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Ch-96Tests 96 Tests
EUR 742

Human C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Hu-48Tests 48 Tests
EUR 388

Human C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Hu-96Tests 96 Tests
EUR 533

Mouse C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Mu-48Tests 48 Tests
EUR 511

Mouse C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Mu-96Tests 96 Tests
EUR 709

Porcine C Reactive Protein (CRP) ELISA Kit

RDR-CRP-p-48Tests 48 Tests
EUR 580

Porcine C Reactive Protein (CRP) ELISA Kit

RDR-CRP-p-96Tests 96 Tests
EUR 807

Rat C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Ra-48Tests 48 Tests
EUR 437

Rat C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Ra-96Tests 96 Tests
EUR 603

Rabbit C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Rb-48Tests 48 Tests
EUR 534

Rabbit C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Rb-96Tests 96 Tests
EUR 742

Bovine C Reactive Protein (CRP) ELISA Kit

RD-CRP-b-48Tests 48 Tests
EUR 555

Bovine C Reactive Protein (CRP) ELISA Kit

RD-CRP-b-96Tests 96 Tests
EUR 771

Chicken C Reactive Protein (CRP) ELISA Kit

RD-CRP-Ch-48Tests 48 Tests
EUR 511

Chicken C Reactive Protein (CRP) ELISA Kit

RD-CRP-Ch-96Tests 96 Tests
EUR 709

Human C Reactive Protein (CRP) ELISA Kit

RD-CRP-Hu-48Tests 48 Tests
EUR 372

Human C Reactive Protein (CRP) ELISA Kit

RD-CRP-Hu-96Tests 96 Tests
EUR 510

Mouse C Reactive Protein (CRP) ELISA Kit

RD-CRP-Mu-48Tests 48 Tests
EUR 489

Mouse C Reactive Protein (CRP) ELISA Kit

RD-CRP-Mu-96Tests 96 Tests
EUR 677

Porcine C Reactive Protein (CRP) ELISA Kit

RD-CRP-p-48Tests 48 Tests
EUR 555

Porcine C Reactive Protein (CRP) ELISA Kit

RD-CRP-p-96Tests 96 Tests
EUR 771

Rat C Reactive Protein (CRP) ELISA Kit

RD-CRP-Ra-48Tests 48 Tests
EUR 419

Rat C Reactive Protein (CRP) ELISA Kit

RD-CRP-Ra-96Tests 96 Tests
EUR 577

Rabbit C Reactive Protein (CRP) ELISA Kit

RD-CRP-Rb-48Tests 48 Tests
EUR 511

Rabbit C Reactive Protein (CRP) ELISA Kit

RD-CRP-Rb-96Tests 96 Tests
EUR 709

Guinea pig C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Gu-48T 48T
EUR 527
  • Should the Guinea pig C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Guinea pig C Reactive Protein (CRP) ELISA Kit

DLR-CRP-Gu-96T 96T
EUR 688
  • Should the Guinea pig C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Guinea pig C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Gu-48Tests 48 Tests
EUR 557

Guinea pig C Reactive Protein (CRP) ELISA Kit

RDR-CRP-Gu-96Tests 96 Tests
EUR 774

Guinea pig C Reactive Protein (CRP) ELISA Kit

RD-CRP-Gu-48Tests 48 Tests
EUR 533

Guinea pig C Reactive Protein (CRP) ELISA Kit

RD-CRP-Gu-96Tests 96 Tests
EUR 740

TruStrip RDT Dog C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack

CRP-RDT-D10 1 pack
EUR 171

TruStrip RDT Human C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack

CRP-RDT-H10 1 pack
EUR 171

TruStrip RDT Human C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack

CRP-RDT-H25 1 pack
EUR 293

TruStrip RDT Monkey C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack

CRP-RDT-M10 1 pack
EUR 171

TruStrip RDT Monkey C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack

CRP-RDT-M25 1 pack
EUR 293

TruStrip RDT Rat C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack

CRP-RDT-R10 1 pack
EUR 171

TruStrip RDT Rat C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack

CRP-RDT-R25 1 pack
EUR 293

CRP/ Rat CRP ELISA Kit

ELA-E0829r 96 Tests
EUR 886

Crp/ Rat Crp ELISA Kit

ELI-02799r 96 Tests
EUR 886

Canine CRP(CRP) ELISA Kit

QY-E70170 96T
EUR 426

CRP protein

30C-CP1000U 1 mg
EUR 349
Description: Purified native Human CRP protein

CRP protein

30R-2081 100 ug
EUR 322
Description: Recombinant human CRP protein

CRP protein

30R-2389 250 ug
EUR 152
Description: Purified recombinant Human CRP protein

CRP protein

30R-2740 10 ug
EUR 341
Description: Purified recombinant Human CRP protein

CRP protein

30R-2984 1 mg
EUR 380
Description: Purified recombinant Human CRP protein

CRP Protein

30R-3412 1 mg
EUR 300
Description: Human C-reactive protein

CRP protein

30R-AC001x 10 mg
EUR 457
Description: Highly purifed Human CRP protein

CRP protein

30R-AC067 1 mg
EUR 448
Description: Purified native Human CRP protein

CRP protein

30-1092 1 mg
EUR 393
Description: Purified recombinant Human CRP protein

CRP protein

30-1094 100 ug
EUR 155
Description: Purified native Human CRP protein

CRP protein

30-1906 1 mg
EUR 336
Description: Native human CRP protein

CRP protein

30-AC05 5 mg
EUR 277
Description: Highly purified Human CRP protein

CRP protein

30-AC07 5 mg
EUR 1029
Description: Purified Recombinant CRP protein

CRP protein

30-AC10 5 mg
EUR 250
Description: Partially purified Human CRP protein

CRP antibody

20C-CR2015S 1 ml
EUR 133
Description: Sheep polyclonal CRP antibody

CRP antibody

20C-CR2015SP 1 ml
EUR 177
Description: Sheep polyclonal CRP antibody

CRP Antibody

31062-100ul 100ul
EUR 252

CRP Antibody

31062-50ul 50ul
EUR 187

CRP antibody

70R-10663 1 ml
EUR 484
Description: Rabbit polyclonal CRP antibody

CRP antibody

70-B9007GA00-A0 5 mg
EUR 241
Description: Goat polyclonal Human CRP antibody

CRP Antibody

6690-100
EUR 338

CRP Antibody

6690-30T
EUR 146

CRP antibody

70R-13710 100 ug
EUR 322
Description: Affinity purified Sheep polyclonal CRP antibody

CRP Antibody

32023-100ul 100ul
EUR 252

CRP antibody

10R-3002 100 ug
EUR 265
Description: Mouse monoclonal CRP antibody

CRP antibody

10R-C189a 1 mg
EUR 284
Description: Mouse monoclonal CRP antibody

CRP antibody

10R-C189b 1 mg
EUR 399
Description: Mouse monoclonal CRP antibody

CRP antibody

10C-CR2015M1 1 mg
EUR 168
Description: Mouse monoclonal CRP antibody

CRP antibody

10C-CR2015M5 1 mg
EUR 165
Description: Mouse monoclonal CRP antibody

CRP antibody

10C-CR2015M6 1 mg
EUR 165
Description: Mouse monoclonal CRP antibody

CRP antibody

10R-10264 50 ug
EUR 241
Description: Mouse monoclonal CRP antibody

CRP antibody

10R-1042 100 ul
EUR 349
Description: Mouse monoclonal CRP antibody

CRP antibody

10-2276 100 ug
EUR 221
Description: Recombinant Fab monoclonal CRP antibody

CRP antibody

10-2349 1 mg
EUR 349
Description: Mouse monoclonal CRP antibody

CRP antibody

10-2350 1 mg
EUR 349
Description: Mouse monoclonal CRP antibody

CRP antibody

10-2703 1 mg
EUR 165
Description: Mouse Monoclonal CRP antibody

CRP antibody

10-7893 1 mg
EUR 392
Description: Mouse monoclonal CRP antibody

CRP antibody

10-7894 1 mg
EUR 403
Description: Mouse monoclonal CRP antibody

CRP antibody

10-C189A 1 mg
EUR 245
Description: Mouse monoclonal CRP antibody

CRP antibody

10-C189B 1 mg
EUR 420
Description: Mouse monoclonal CRP antibody

CRP antibody

10-C33A 1 mg
EUR 238
Description: Mouse monoclonal CRP antibody