Phytoestrogens protect joints in collagen induced arthritis by increasing IgG glycosylation and reducing osteoclast activation.

Based on previous studies, we know that estrogen can protect the joints from arthritis development by increasing IgG glycosylation and inhibiting osteoclast activation. Phytoestrogens, especially genistein and daidzein, are structurally similar to estradiol that can bind to estrogen receptors (ERs). However, how phytoestrogens affect IgG glycosylation and osteoclast activation in vivo are not investigated so far. In this study, we used 20 mg/kg genistein or daidzein to gavage the female DBA1/J mice in collagen induced arthritis (CIA). We assessed arthritis and bone erosion by clinical scores, histopathology, and micro-CT analysis. Inflammatory cells such as neutrophils, B cells, macrophages and T cells in the peripheral blood were analyzed by flow cytometry. Phagocytic function of peritoneal macrophages was assessed by using FITC-labeled Escherichia coli. New monoclonal antibodies against CII were produced, purified and analyzed. Glycosylation levels of polyclonal and monoclonal IgG were detected by lectin-ELISA. Quantitative PCR was used to analyze the genes related to IgG glycosylation (B4galt1, St6gal1) and osteoclasts (TRAP, NFATC1, c-Fos). Expression of NF-κB and Akt signaling pathways as well as downstream transcription factors NFATc1 and c-Fos was studied by Western blot. Our results show that phytoestrogens protect mice from CIA by increasing IgG glycosylation leading to amelioration of inflammation and inhibiting the NF-κB pathway and NFATc1/c-Fos to decrease the activity of osteoclasts. In conclusion, phytoestrogens can protect bone and joints in CIA mice by increasing IgG glycosylation and inhibiting osteoclast activity.

Bovine C Reactive Protein (CRP) ELISA Kit
DLR-CRP-b-96T	DL Develop	96T	EUR 715
Should the Bovine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ch-48T	DL Develop	48T	EUR 508
Should the Chicken C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Chicken C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ch-96T	DL Develop	96T	EUR 661
Should the Chicken C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Human C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Hu-48T	DL Develop	48T	EUR 385
Should the Human C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, urine, cerebrospinal fluid, cell culture supernates or other biological fluids.

Human C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Hu-96T	DL Develop	96T	EUR 492
Should the Human C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, urine, cerebrospinal fluid, cell culture supernates or other biological fluids.

Mouse C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Mu-48T	DL Develop	48T	EUR 489
Should the Mouse C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Mu-96T	DL Develop	96T	EUR 635
Should the Mouse C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine C Reactive Protein (CRP) ELISA Kit
DLR-CRP-p-48T	DL Develop	48T	EUR 547
Should the Porcine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine C Reactive Protein (CRP) ELISA Kit
DLR-CRP-p-96T	DL Develop	96T	EUR 715
Should the Porcine C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ra-48T	DL Develop	48T	EUR 426
Should the Rat C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Ra-96T	DL Develop	96T	EUR 549
Should the Rat C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat C Reactive Protein (CRP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Rb-48T	DL Develop	48T	EUR 508
Should the Rabbit C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Rabbit C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Rb-96T	DL Develop	96T	EUR 661
Should the Rabbit C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Bovine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-b-48Tests	Reddot Biotech	48 Tests	EUR 580

Bovine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-b-96Tests	Reddot Biotech	96 Tests	EUR 807

Chicken C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ch-48Tests	Reddot Biotech	48 Tests	EUR 534

Chicken C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ch-96Tests	Reddot Biotech	96 Tests	EUR 742

Human C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Hu-48Tests	Reddot Biotech	48 Tests	EUR 388

Human C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Hu-96Tests	Reddot Biotech	96 Tests	EUR 533

Mouse C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511

Mouse C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709

Porcine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-p-48Tests	Reddot Biotech	48 Tests	EUR 580

Porcine C Reactive Protein (CRP) ELISA Kit
RDR-CRP-p-96Tests	Reddot Biotech	96 Tests	EUR 807

Rat C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ra-48Tests	Reddot Biotech	48 Tests	EUR 437

Rat C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Ra-96Tests	Reddot Biotech	96 Tests	EUR 603

Rabbit C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Rb-48Tests	Reddot Biotech	48 Tests	EUR 534

Rabbit C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Rb-96Tests	Reddot Biotech	96 Tests	EUR 742

Bovine C Reactive Protein (CRP) ELISA Kit
RD-CRP-b-48Tests	Reddot Biotech	48 Tests	EUR 555

Bovine C Reactive Protein (CRP) ELISA Kit
RD-CRP-b-96Tests	Reddot Biotech	96 Tests	EUR 771

Chicken C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ch-48Tests	Reddot Biotech	48 Tests	EUR 511

Chicken C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ch-96Tests	Reddot Biotech	96 Tests	EUR 709

Human C Reactive Protein (CRP) ELISA Kit
RD-CRP-Hu-48Tests	Reddot Biotech	48 Tests	EUR 372

Human C Reactive Protein (CRP) ELISA Kit
RD-CRP-Hu-96Tests	Reddot Biotech	96 Tests	EUR 510

Mouse C Reactive Protein (CRP) ELISA Kit
RD-CRP-Mu-48Tests	Reddot Biotech	48 Tests	EUR 489

Mouse C Reactive Protein (CRP) ELISA Kit
RD-CRP-Mu-96Tests	Reddot Biotech	96 Tests	EUR 677

Porcine C Reactive Protein (CRP) ELISA Kit
RD-CRP-p-48Tests	Reddot Biotech	48 Tests	EUR 555

Porcine C Reactive Protein (CRP) ELISA Kit
RD-CRP-p-96Tests	Reddot Biotech	96 Tests	EUR 771

Rat C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ra-48Tests	Reddot Biotech	48 Tests	EUR 419

Rat C Reactive Protein (CRP) ELISA Kit
RD-CRP-Ra-96Tests	Reddot Biotech	96 Tests	EUR 577

Rabbit C Reactive Protein (CRP) ELISA Kit
RD-CRP-Rb-48Tests	Reddot Biotech	48 Tests	EUR 511

Rabbit C Reactive Protein (CRP) ELISA Kit
RD-CRP-Rb-96Tests	Reddot Biotech	96 Tests	EUR 709

Guinea pig C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Gu-48T	DL Develop	48T	EUR 527
Should the Guinea pig C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Guinea pig C Reactive Protein (CRP) ELISA Kit
DLR-CRP-Gu-96T	DL Develop	96T	EUR 688
Should the Guinea pig C Reactive Protein (CRP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig C Reactive Protein (CRP) in samples from serum, plasma or other biological fluids.

Guinea pig C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Gu-48Tests	Reddot Biotech	48 Tests	EUR 557

Guinea pig C Reactive Protein (CRP) ELISA Kit
RDR-CRP-Gu-96Tests	Reddot Biotech	96 Tests	EUR 774

Guinea pig C Reactive Protein (CRP) ELISA Kit
RD-CRP-Gu-48Tests	Reddot Biotech	48 Tests	EUR 533

Guinea pig C Reactive Protein (CRP) ELISA Kit
RD-CRP-Gu-96Tests	Reddot Biotech	96 Tests	EUR 740

TruStrip RDT Dog C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-D10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Human C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-H10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Human C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack
CRP-RDT-H25	Alpha Diagnostics	1 pack	EUR 293

TruStrip RDT Monkey C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-M10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Monkey C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack
CRP-RDT-M25	Alpha Diagnostics	1 pack	EUR 293

TruStrip RDT Rat C-reactive Protein (CRP) Rapid Test cards, 10 tests/pack
CRP-RDT-R10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Rat C-reactive Protein (CRP) Rapid Test cards, 25 tests/pack
CRP-RDT-R25	Alpha Diagnostics	1 pack	EUR 293

CRP/ Rat CRP ELISA Kit
ELA-E0829r	Lifescience Market	96 Tests	EUR 886

Crp/ Rat Crp ELISA Kit
ELI-02799r	Lifescience Market	96 Tests	EUR 886

Canine CRP(CRP) ELISA Kit
QY-E70170	Qayee Biotechnology	96T	EUR 426

CRP protein
30C-CP1000U	Fitzgerald	1 mg	EUR 349
Description: Purified native Human CRP protein

CRP protein
30R-2081	Fitzgerald	100 ug	EUR 322
Description: Recombinant human CRP protein

CRP protein
30R-2389	Fitzgerald	250 ug	EUR 152
Description: Purified recombinant Human CRP protein

CRP protein
30R-2740	Fitzgerald	10 ug	EUR 341
Description: Purified recombinant Human CRP protein

CRP protein
30R-2984	Fitzgerald	1 mg	EUR 380
Description: Purified recombinant Human CRP protein

CRP Protein
30R-3412	Fitzgerald	1 mg	EUR 300
Description: Human C-reactive protein

CRP protein
30R-AC001x	Fitzgerald	10 mg	EUR 457
Description: Highly purifed Human CRP protein

CRP protein
30R-AC067	Fitzgerald	1 mg	EUR 448
Description: Purified native Human CRP protein

CRP protein
30-1092	Fitzgerald	1 mg	EUR 393
Description: Purified recombinant Human CRP protein

CRP protein
30-1094	Fitzgerald	100 ug	EUR 155
Description: Purified native Human CRP protein

CRP protein
30-1906	Fitzgerald	1 mg	EUR 336
Description: Native human CRP protein

CRP protein
30-AC05	Fitzgerald	5 mg	EUR 277
Description: Highly purified Human CRP protein

CRP protein
30-AC07	Fitzgerald	5 mg	EUR 1029
Description: Purified Recombinant CRP protein

CRP protein
30-AC10	Fitzgerald	5 mg	EUR 250
Description: Partially purified Human CRP protein

CRP antibody
20C-CR2015S	Fitzgerald	1 ml	EUR 133
Description: Sheep polyclonal CRP antibody

CRP antibody
20C-CR2015SP	Fitzgerald	1 ml	EUR 177
Description: Sheep polyclonal CRP antibody

CRP Antibody
31062-100ul	SAB	100ul	EUR 252

CRP Antibody
31062-50ul	SAB	50ul	EUR 187

CRP antibody
70R-10663	Fitzgerald	1 ml	EUR 484
Description: Rabbit polyclonal CRP antibody

CRP antibody
70-B9007GA00-A0	Fitzgerald	5 mg	EUR 241
Description: Goat polyclonal Human CRP antibody

CRP Antibody
6690-100	Biovision		EUR 338

CRP Antibody
6690-30T	Biovision		EUR 146

CRP antibody
70R-13710	Fitzgerald	100 ug	EUR 322
Description: Affinity purified Sheep polyclonal CRP antibody

CRP Antibody
32023-100ul	SAB	100ul	EUR 252

CRP antibody
10R-3002	Fitzgerald	100 ug	EUR 265
Description: Mouse monoclonal CRP antibody

CRP antibody
10R-C189a	Fitzgerald	1 mg	EUR 284
Description: Mouse monoclonal CRP antibody

CRP antibody
10R-C189b	Fitzgerald	1 mg	EUR 399
Description: Mouse monoclonal CRP antibody

CRP antibody
10C-CR2015M1	Fitzgerald	1 mg	EUR 168
Description: Mouse monoclonal CRP antibody

CRP antibody
10C-CR2015M5	Fitzgerald	1 mg	EUR 165
Description: Mouse monoclonal CRP antibody

CRP antibody
10C-CR2015M6	Fitzgerald	1 mg	EUR 165
Description: Mouse monoclonal CRP antibody

CRP antibody
10R-10264	Fitzgerald	50 ug	EUR 241
Description: Mouse monoclonal CRP antibody

CRP antibody
10R-1042	Fitzgerald	100 ul	EUR 349
Description: Mouse monoclonal CRP antibody

CRP antibody
10-2276	Fitzgerald	100 ug	EUR 221
Description: Recombinant Fab monoclonal CRP antibody

CRP antibody
10-2349	Fitzgerald	1 mg	EUR 349
Description: Mouse monoclonal CRP antibody

CRP antibody
10-2350	Fitzgerald	1 mg	EUR 349
Description: Mouse monoclonal CRP antibody

CRP antibody
10-2703	Fitzgerald	1 mg	EUR 165
Description: Mouse Monoclonal CRP antibody

CRP antibody
10-7893	Fitzgerald	1 mg	EUR 392
Description: Mouse monoclonal CRP antibody

CRP antibody
10-7894	Fitzgerald	1 mg	EUR 403
Description: Mouse monoclonal CRP antibody

CRP antibody
10-C189A	Fitzgerald	1 mg	EUR 245
Description: Mouse monoclonal CRP antibody

CRP antibody
10-C189B	Fitzgerald	1 mg	EUR 420
Description: Mouse monoclonal CRP antibody

CRP antibody
10-C33A	Fitzgerald	1 mg	EUR 238
Description: Mouse monoclonal CRP antibody