Binding of naturally occurring anti-DNA antibodies to estradiol.

Binding of naturally occurring human anti-DNA autoantibodies to beta-estradiol and native DNA has been investigated. Sera from seven SLE sufferers had been examined for his or her reactivity with beta-estradiol and native calf thymus DNA. Solid Phase enzyme immunoassay was carried out utilizing each colorigenic and fluorogenic substrates. The outcomes present enhanced binding of human anti-DNA autoantibodies to beta-estradiol as in contrast to native DNA. This was additional substantiated by elevated binding of affinity purified SLE IgG to beta-estradiol. These outcomes recommend a task for feminine intercourse hormone within the etiopathogenesis of SLE and are vital vis-a-vis feminine predominance of SLE.

Structural evaluation of an anti-estradiol antibody.

An anti-estradiol antibody with improved specificity is looked for by combining steroid analog binding research, mutant antibodies obtained from a phage-display library and structural modeling. Three-dimensional fashions for the anti-estradiol antibody 57-2 had been constructed by comparative mannequin constructing. Estradiol and analogs had been docked into the combining website and molecular dynamics simulation was used to additional refine this space of the protein. Cross-reactivities measured in opposition to 36 steroid analogs had been used to assist in the docking course of and to consider the fashions.
The roles of a quantity of residues had been assessed by characterization of cross-reactivity mutants obtained from a phage show library. The cross-reactivity information and the outcomes noticed for mutants are defined by the structural mannequin, wherein the estradiol D-ring inserts deeply into the binding website and interacts with the antibody by at the very least one particular hydrogen bond. The binding information strongly recommend that this hydrogen bond connects the estradiol 17-hydroxyl group with the facet chain of Gln H35. As anticipated for the binding of a small fragrant molecule, the antibody binding website comprises many fragrant residues, e.g. Trp H50, H95 and L96 and Tyr L32, L49 and Phe L91.

Direct colorimetric monoclonal antibody enzyme immunoassay for estradiol-17 beta in saliva.

We developed a direct microtiter plate enzyme immunoassay to measure estradiol-17 beta in saliva. The assay has a commercially obtainable monoclonal antibody, raised in opposition to estradiol-17 beta-6-carboxymethyloximebovine serum albumin, and a homologous horseradish peroxidase conjugate measured colorimetrically. The detection restrict (equal to B0-Three SD) is 365 amol/nicely or 7.Three pmol/L when 50-microL samples are assayed.
Cross-reactivity with estrone and estriol, testosterone, or progesterone is < 0.2%. Estradiol-17 beta was measured in day by day samples over 5 pure menstrual cycles and eight cycles stimulated as a preliminary to in vitro fertilization, and the concentrations and fluctuations discovered agreed with beforehand printed information. This technique offers leads to roughly Three h and could also be helpful for fertility monitoring and administration. IgG subisotype evaluation confirmed IgG2b to be predominant. In abstract, our findings recommend that estrogen, however not dihydrotestosterone, promotes anti-dsDNA antibodies in regular mice.

Retrieval of estradiol receptor in paraffin sections of resting porcine uteri by microwave remedy. Immunostaining patterns obtained with totally different main antibodies.

The unmasking of estradiol receptor in paraffin sections of Bouin’s-fixed uterine tissue from ovariectomized gilts was attained with microwave remedy. Immunocytochemistry of the receptor was carried out utilizing a polyclonal or 5 monoclonal antibodies, two of that are commercially obtainable, reacting with totally different domains of the protein and an amplified-peroxidase system for detection. With 5 of the antibodies, a predominance of nuclear staining was noticed in cells of endometrial glands, whereas one monoclonal antibody (13H2), reacting with the receptor’s area E, confirmed a desire for the cytoplasmic receptor.
In stroma, all antibodies detected extra receptor in nuclei than in cytoplasm. In epithelium, the commercially obtainable antibody H222, our monoclonals 13H2 and HT65, and the polyclonal antibody 402 demonstrated extra receptor in cytoplasmic than in nuclear areas. In myometrium, the nuclei from longitudinal and ring muscle mass had been undoubtedly stained with the antibodies. We conclude that the accessibilities of the antibody epitopes of the receptor differ in accordance to the purposeful uterine cell kind.
Binding of naturally occurring anti-DNA antibodies to estradiol.

17 beta-estradiol, however not 5 alpha-dihydrotestosterone, augments antibodies to double-stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice.

The affect of intercourse hormones on the immune response to overseas antigens in addition to self-antigens is now acknowledged. In this examine, we investigated the affect of gender and intercourse hormones on the event of antibodies to double-stranded DNA in nonautoimmune C57BL/6J mice. Immunoglobulin G (IgG) anti-dsDNA antibodies are generally current in lupus sufferers and a number of other autoimmune disease-prone murine strains. We discovered that C57BL/6J mice have detectable antibodies (IgM and IgG, however not IgA) to dsDNA. Interestingly, the incidence and degree of IgG anti-dsDNA antibodies had been decrease in male than in feminine mice.
Orchidectomy or administration of 5 alpha-dihydrotestosterone to orchidectomized male mice had minimal results on these antibodies. In distinction, administration of 17 beta-estradiol to orchidectomized or intact males considerably elevated each the incidence and ranges of anti-dsDNA antibodies. In feminine mice, ovariectomy decreased whereas administration of estrogen augmented the incidence and ranges of anti-dsDNA antibodies in ovariectomized in addition to intact feminine mice. Kinetic research revealed that estrogen remedy of female and male mice induced earlier and sustained expression of IgG anti-dsDNA antibodies in contrast to controls.

Investigation of a 17 beta-estradiol-monoclonal antiestradiol antibody binding mechanism utilizing dilute options of natural solvents.

Quantitative understanding of steroid hormone transport and receptor-mediated motion requires data of the bonding forces concerned in every steroid-protein advanced and the consequences of a organic atmosphere on these forces. An method to these issues utilizing dilute options of water-miscible natural solvents, with a variety of polarity, dielectric and hydrogen bonding properties, was examined on an estradiol-antiestradiol antibody binding system on the idea that evaluating the consequences of the solvents would each allow the significance of hydrophobic and hydrogen bonding to be differentiated and provides info on the consequences of the atmosphere on the response. The outcomes had been in contrast with thermodynamic measurements.
All the solvents decreased the Gibbs free power of binding as a perform of their focus within the medium. The decreases had been nearly a monotonic perform of their dielectric fixed, indicating decreased hydrogen bonding. Analysis of the decreases in phrases of the solvents’ hydrogen bonding and polarity properties supported this. Thermodynamic measurement confirmed the binding response was enthalpy-driven with, total, a barely unfavorable entropy contribution. This once more confirmed the hydrophobic impact was not the primary bonding drive.

Cyclopropyl Hydrazine Hydrochloride

abx188669-100g 100 g
EUR 2054
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(2-Fluorobenzyl)hydrazine hydrochloride

abx180090-10g 10 g
EUR 370
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(4-Methoxybenzyl)hydrazine hydrochloride

20-abx181427
  • EUR 481.00
  • EUR 342.00
  • 10 g
  • 5 g
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2,3-Dichlorophenyl hydrazine hydrochloride

20-abx181633
  • EUR 578.00
  • EUR 328.00
  • 100 g
  • 25 g
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(3-Nitrophenyl)hydrazine hydrochloride

20-abx184852
  • EUR 384.00
  • EUR 230.00
  • EUR 189.00
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  • 5 g
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4-Fluorphenyl hydrazine hydrochloride

20-abx185223
  • EUR 230.00
  • EUR 314.00
  • 100 g
  • 250 g
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4-Trifluoromethylphenyl hydrazine hydrochloride

20-abx185244
  • EUR 384.00
  • EUR 230.00
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(4-Iodophenyl)Hydrazine Hydrochloride

abx188013-500g 500 g
EUR 996
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4-Bromophenyl hydrazine hydrochloride

20-abx183549
  • EUR 258.00
  • EUR 203.00
  • EUR 175.00
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(4-BroMo-3-fluorophenyl)hydrazine Hydrochloride

20-abx182736
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Hydrazine,(2-chloro-4-fluorophenyl)-, hydrochloride (1:1)

20-abx180781
  • EUR 759.00
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  • 100 g
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Hydrazine,(3-chloro-2-fluorophenyl)-, hydrochloride (1:1)

20-abx181296
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Hydrazine,(5-chloro-2-fluorophenyl)-, hydrochloride (1:1)

20-abx182486
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Hydrazine monohydrochloride

20-abx184117
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  • EUR 342.00
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

20-abx186150
  • EUR 690.00
  • EUR 356.00
  • 100 mg
  • 25 mg
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(4-Chlorophenyl)hydrazine

20-abx180930
  • EUR 411.00
  • EUR 258.00
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(3,4-Dimethylphenyl)hydrazine

20-abx182729
  • EUR 328.00
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  • EUR 189.00
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S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

C5660-10 10 mg
EUR 112
Description: S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) is a selective and competitive nNOS inhibitor with Ki value of 0.32 ?M for the purified human enzyme [1].

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

C5660-100 100 mg
EUR 537
Description: S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) is a selective and competitive nNOS inhibitor with Ki value of 0.32 ?M for the purified human enzyme [1].

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

C5660-25 25 mg
EUR 187
Description: S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) is a selective and competitive nNOS inhibitor with Ki value of 0.32 ?M for the purified human enzyme [1].

(4-((2-(Diethylamino)Ethyl)Carbamoyl)Phenyl)Boronic Acid Hydrochloride

20-abx187985
  • EUR 300.00
  • EUR 634.00
  • 1 g
  • 5 g
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(4-Chlorobenzyl)hydrazine dihydrochloride

20-abx181426
  • EUR 954.00
  • EUR 314.00
  • EUR 634.00
  • 10 g
  • 1 g
  • 5 g
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(4-(Bromomethyl)Phenyl)(Phenyl)Methanone

abx187996-500g 500 g
EUR 1776
  • Shipped within 1-2 weeks.

(3-((1H-Tetrazol-5-Yl)Carbamoyl)Phenyl)Boronic Acid Hydrochloride

20-abx187961
  • EUR 258.00
  • EUR 565.00
  • 1 g
  • 5 g
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(4-((4-Methylpiperazin-1-Yl)Carbamoyl)Phenyl)Boronic Acid Hydrochloride

20-abx187993
  • EUR 328.00
  • EUR 871.00
  • 1 g
  • 5 g
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(4-tert-Butyl-phenyl)-phenyl-amine

20-abx181430
  • EUR 356.00
  • EUR 732.00
  • 1 g
  • 5 g
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Phenyl sulfate

B6050-25 25 mg
EUR 1210

Phenyl sulfate

B6050-5 5 mg
EUR 456

Phenyl Bromoacetate

abx188833-1kg 1 kg
EUR 620
  • Shipped within 1-2 weeks.

Phenyl-benzothiazole

B7851-1000 1 g
EUR 189

(4-Bromo-3-fluorophenyl)hydrazine

20-abx186089
  • EUR 1107.00
  • EUR 2987.00
  • 1 g
  • 5 g
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N-biotinoyl-N-(maleimidohexanoyl)hydrazine

abx187867-1g 1 g
EUR 1344
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(4-((4H-1,2,4-Triazol-4-Yl)Carbamoyl)Phenyl)Boronic Acid Hydrochloride

20-abx187992
  • EUR 328.00
  • EUR 954.00
  • 1 g
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(4-((4-(Trifluoromethoxy)Phenyl)Carbamoyl)Phenyl)Boronic Acid

20-abx187990
  • EUR 398.00
  • EUR 954.00
  • 1 g
  • 5 g
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Cellufine MAX Phenyl

20700 100 ml
EUR 366

Cellufine MAX Phenyl

20701 500 ml
EUR 995

Cellufine MAX Phenyl

20702 5 lt Ask for price

Cellufine MAX Phenyl

20703 10 lt Ask for price

S-Phenyl Thioacetate

20-abx188887
  • EUR 1247.00
  • EUR 203.00
  • EUR 565.00
  • EUR 314.00
  • 100 g
  • 1 g
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  • 5 g
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N-Phenyl isonicotinicamide

20-abx180061
  • EUR 314.00
  • EUR 592.00
  • 1 g
  • 5 g
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Methyl phenyl sulfone

20-abx181322
  • EUR 537.00
  • EUR 286.00
  • EUR 1219.00
  • EUR 230.00
  • 100 g
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  • 5 g
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Ethyl phenyl sulfide

20-abx184689
  • EUR 258.00
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  • 100 g
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Cyclohexyl phenyl ketone

20-abx182405
  • EUR 356.00
  • EUR 230.00
  • 100 g
  • 25 g
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Phenyl-benzothiazole HCl

A8770-1000 1 g
EUR 189

Phenyl isothiocyanate, 99%

GX7854-5ML 5 ml
EUR 118

(Tetrahydro-2H-pyran-4-yl)hydrazine dihydrochloride

20-abx180120
  • EUR 467.00
  • EUR 996.00
  • 1 g
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1-(2-BroMo-4-Methylphenyl)hydrazine, HCl

20-abx182804
  • EUR 314.00
  • EUR 1233.00
  • EUR 606.00
  • 1 g
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  • 5 g
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Cellufine MAX Phenyl LS

20800 100 ml
EUR 366

Cellufine MAX Phenyl LS

20801 500 ml
EUR 995

Cellufine MAX Phenyl LS

20802 5 lt Ask for price

Cellufine MAX Phenyl LS

20803 10 lt Ask for price

MC Cellufine MAX Phenyl

20-700-51 5 x 1 ml
EUR 271

MC Cellufine MAX Phenyl

20-700-55 5 x 5 ml
EUR 537

H-Cys(phenyl)-OH

E-3400.0001 1.0g
EUR 176
Description: Sum Formula: C9H11NO2S; CAS# [34317-61-8]

H-Cys(phenyl)-OH

E-3400.0005 5.0g
EUR 587
Description: Sum Formula: C9H11NO2S; CAS# [34317-61-8]

Boc-Glu-phenyl ester

A-4540.0001 1.0g
EUR 151
Description: Sum Formula: C16H21NO6; CAS# [59587-94-9]

Boc-Glu-phenyl ester

A-4540.0005 5.0g
EUR 526
Description: Sum Formula: C16H21NO6; CAS# [59587-94-9]

4-(Trifluoromethoxy)Phenyl Isothiocyanate

abx188418-50g 50 g
EUR 523
  • Shipped within 1-2 weeks.

1-Phenyl-1,2-propanedione

20-abx180022
  • EUR 481.00
  • EUR 230.00
  • 100 g
  • 10 g
  • Shipped within 1-2 weeks.

4-(Maleinimido)Phenyl Isocyanate

abx180470-1g 1 g
EUR 2012
  • Shipped within 1-2 weeks.

N-phenyl-2-naphthylamine

20-abx181333
  • EUR 217.00
  • EUR 189.00
  • EUR 328.00
  • 100 g
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  • 500 g
  • Shipped within 1-2 weeks.

5-Phenyl-1H-tetrazole

abx184628-500g 500 g
EUR 314
  • Shipped within 1-2 weeks.

2-Phenyl-1,3-Dioxolane

20-abx185083
  • EUR 871.00
  • EUR 2291.00
  • 1 g
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Phenyl-(2-Pyridyl)Acetamide

20-abx185536
  • EUR 356.00
  • EUR 565.00
  • EUR 272.00
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2-Phenyl-2-Propanol

20-abx186243
  • EUR 592.00
  • EUR 342.00
  • EUR 230.00
  • 100 g
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  • Shipped within 1-2 weeks.

4-phenyl-1,2,3-Thiadiazole

C4691-1000 1 g
EUR 135

4-phenyl-1,2,3-Thiadiazole

C4691-5000 5 g
EUR 428

N-Phenyl-bis(trifluoromethanesulfonimide)

GX3512-5G 5 g
EUR 70

Phenyl b-D-thioglucopyranoside

GC0722-100MG 100 mg
EUR 94

Phenyl b-D-thioglucopyranoside

GC0722-1G 1 g
EUR 341

Phenyl b-D-thioglucopyranoside

GC0722-250MG 250 mg
EUR 150

Phenyl b-D-thioglucopyranoside

GC0722-500MG 500 mg
EUR 205

Phenyl b-D-thioglucopyranoside

GC0722-50MG 50 mg
EUR 70

Phenyl b-D-glucopyranoside

GC6682-25G 25 g
EUR 229

Phenyl b-D-glucopyranoside

GC6682-5G 5 g
EUR 86

4-(Trifluoromethyl)phenyl isothiocyanate

GK7826-5G 5 g
EUR 109

MC Cellufine MAX Phenyl LS

20-800-51 5 x 1 ml
EUR 271

MC Cellufine MAX Phenyl LS

20-800-55 5 x 5 ml
EUR 537

Fmoc-4-phenyl-Phe-OH

B-3155.0001 1.0g
EUR 418
Description: Sum Formula: C30H25NO4; CAS# [199110-64-0]

Fmoc-4-phenyl-Phe-OH

B-3155.0005 5.0g
EUR 1554
Description: Sum Formula: C30H25NO4; CAS# [199110-64-0]

Boc-4-phenyl-Phe-OH

A-4385.0001 1.0g
EUR 490
Description: Sum Formula: C20H23NO4; CAS# [147923-08-8]

Boc-4-phenyl-Phe-OH

A-4385.0005 5.0g
EUR 1844
Description: Sum Formula: C20H23NO4; CAS# [147923-08-8]

Amino-(2-Chloro-Phenyl)-Aceticacid

abx188588-5000g 5000 g
EUR 773
  • Shipped within 1-2 weeks.

3-(4-Carboethoxy)phenyl propanal

20-abx180030
  • EUR 342.00
  • EUR 787.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(2-Chloro-Phenyl)-Acetamidine

20-abx180204
  • EUR 328.00
  • EUR 704.00
  • 1 g
  • 5 g
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1-(4-(Difluoromethoxy)phenyl)ethanone

20-abx180943
  • EUR 565.00
  • EUR 244.00
  • EUR 398.00
  • 10 g
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

(4-(tert-Butyl)phenyl)methanol

20-abx181420
  • EUR 690.00
  • EUR 272.00
  • EUR 230.00
  • 100 g
  • 10 g
  • 5 g
  • Shipped within 1-2 weeks.

3-[4-(trifluoromethoxy)phenyl]propanoicacid

20-abx181879
  • EUR 217.00
  • EUR 356.00
  • 1 g
  • 5 g
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4-Chloro-2-phenyl-pyrimidine

20-abx182082
  • EUR 885.00
  • EUR 634.00
  • 1 g
  • 500 mg
  • Shipped within 1-2 weeks.

2-(3-Fluoro-phenyl)-ethylamine

20-abx185696
  • EUR 592.00
  • EUR 314.00
  • EUR 203.00
  • 100 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(4-Chloro-phenyl)-ethylamine

20-abx185697
  • EUR 509.00
  • EUR 189.00
  • EUR 258.00
  • EUR 203.00
  • 100 g
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(4-Methoxy-phenyl)-ethylamine

20-abx185698
  • EUR 398.00
  • EUR 244.00
  • 100 g
  • 25 g
  • Shipped within 1-2 weeks.

(2-Chloro-Phenyl)-Oxo-Acetonitrile

20-abx186083
  • EUR 328.00
  • EUR 732.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

(2-Fluoro-Phenyl)-Methanesulfonyl Chloride

abx187958-1g 1 g
EUR 370
  • Shipped within 1-2 weeks.

[4-(Methoxycarbamoyl)Phenyl]Boronic Acid

20-abx188057
  • EUR 300.00
  • EUR 634.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(Aminomethyl)Phenyl Boronic Acid

abx188153-1g 1 g
EUR 1080
  • Shipped within 1-2 weeks.

[3-(Dimethylamino)Phenyl]-Boronic Acid

20-abx182795
  • EUR 384.00
  • EUR 217.00
  • EUR 300.00
  • 10 g
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

[3-(Methylcarbamoyl)Phenyl]Boronic Acid

20-abx182796
  • EUR 230.00
  • EUR 746.00
  • EUR 342.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

[4-(Morpholinomethyl)Phenyl]Boronic Acid

20-abx182798
  • EUR 258.00
  • EUR 384.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

[4-(Phenylcarbonyl)Phenyl]Boronic Acid

20-abx182799
  • EUR 203.00
  • EUR 829.00
  • EUR 328.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(3-Bromo-phenyl)-ethylamine

20-abx182924
  • EUR 244.00
  • EUR 871.00
  • EUR 398.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(4-Chloro-phenyl)-pyrrolidine

20-abx182926
  • EUR 509.00
  • EUR 3293.00
  • EUR 1205.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

H-4-Phenyl-Phe-OH

F-3645.0001 1.0g
EUR 418
Description: Sum Formula: C15H15NO2; CAS# [155760-02-4]

H-4-Phenyl-Phe-OH

F-3645.0005 5.0g
EUR 1554
Description: Sum Formula: C15H15NO2; CAS# [155760-02-4]

Phenyl phosphate disodium salt dihydrate

GE1672-100G 100 g
EUR 150

Phenyl phosphate disodium salt dihydrate

GE1672-10G 10 g
EUR 52

Phenyl phosphate disodium salt dihydrate

GE1672-25G 25 g
EUR 74

Phenyl phosphate disodium salt dihydrate

GE1672-50G 50 g
EUR 99

(S)-(+)-4-Phenyl-2-oxazolidinone

GK1601-100G 100 g
EUR 181

(S)-(+)-4-Phenyl-2-oxazolidinone

GK1601-25G 25 g
EUR 94

NuGel™ Phenyl Boronic Acid

NPBA-05 5g
EUR 679
Description: Glycoprotein Enrichment kit

NuGel™ Phenyl Boronic Acid

NPBA-10 10g
EUR 953
Description: Glycoprotein Enrichment kit

Purified GFP

AG45-0205-Z 0.1 mg
EUR 228

Ovalbumin, purified

O705084 1g
EUR 67.4
  • Product category: Proteins/Recombinant Proteins/Other

Fmoc-4-phenyl-D-Phe-OH

B-3160.0001 1.0g
EUR 660
Description: Sum Formula: C30H25NO4; CAS# [205526-38-1]

Fmoc-4-phenyl-D-Phe-OH

B-3160.0005 5.0g
EUR 2533
Description: Sum Formula: C30H25NO4; CAS# [205526-38-1]

Boc-4-phenyl-D-Phe-OH

A-4390.0001 1.0g
EUR 599
Description: Sum Formula: C20H23NO4; CAS# [128779-47-5]

Boc-4-phenyl-D-Phe-OH

A-4390.0005 5.0g
EUR 2316
Description: Sum Formula: C20H23NO4; CAS# [128779-47-5]

H-4-Phenyl-L-Phe-Oh

20-abx188725
  • EUR 1261.00
  • EUR 634.00
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

2-Phenyl-imidazo[1,2-a]pyridine

20-abx180360
  • EUR 425.00
  • EUR 926.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

(S)-alpha-Bromo-alpha-phenyl acetonitrile

20-abx181469
  • EUR 648.00
  • EUR 1609.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

3-Phenyl-1H-pyrazole-4-carbaldehyde

20-abx181988
  • EUR 439.00
  • EUR 244.00
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

{4-[(dimethylamino)sulfonyl]phenyl}boronic acid

20-abx184894
  • EUR 286.00
  • EUR 1483.00
  • EUR 551.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

2-(4-Dihydroxyborane)Phenyl-4-Carboxyquinoline

20-abx185622
  • EUR 537.00
  • EUR 286.00
  • 1 g
  • 250 mg
  • Shipped within 1-2 weeks.

4-Bromo-1-phenyl-1H-pyrazole

20-abx185942
  • EUR 1107.00
  • EUR 467.00
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

[3-(3-Pyridinylcarbamoyl)Phenyl]Boronic Acid

20-abx188049
  • EUR 328.00
  • EUR 801.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

[4-(3-Pentanylcarbamoyl)Phenyl]Boronic Acid

20-abx188055
  • EUR 328.00
  • EUR 954.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

3-Phenyl-2-(Phenylsulfonyl)-1,2-Oxaziridine

abx188398-1g 1 g
EUR 342
  • Shipped within 1-2 weeks.

H-4-Phenyl-D-Phe-OH

20-abx184102
  • EUR 704.00
  • EUR 1762.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

2-Phenyl-2-(1-piperidinyl)propane

C5047-10 10 mg
EUR 440
Description: KI: 11 microM for 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats 2-Phenyl-2-(1-piperidinyl)propane is a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6.

2-Phenyl-2-(1-piperidinyl)propane

C5047-25 25 mg
EUR 902
Description: KI: 11 microM for 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats 2-Phenyl-2-(1-piperidinyl)propane is a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6.

2-Phenyl-2-(1-piperidinyl)propane

C5047-5 5 mg
EUR 257
Description: KI: 11 microM for 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats 2-Phenyl-2-(1-piperidinyl)propane is a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6.

4-phenyl-5-methyl-1,2,3-Thiadiazole

C4429-1000 1 g
EUR 100
Description: 4-phenyl-5-methyl-1,2,3-Thiadiazole is a CYP2B4 and CYP2E1 inhibitor.

4-phenyl-5-methyl-1,2,3-Thiadiazole

C4429-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: 4-phenyl-5-methyl-1,2,3-Thiadiazole is a CYP2B4 and CYP2E1 inhibitor.

4-phenyl-5-methyl-1,2,3-Thiadiazole

C4429-5000 5 g
EUR 274
Description: 4-phenyl-5-methyl-1,2,3-Thiadiazole is a CYP2B4 and CYP2E1 inhibitor.

3-bromo-5-phenyl Salicylic Acid

C4516-1 1 mg
EUR 121
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

3-bromo-5-phenyl Salicylic Acid

C4516-10 10 mg
EUR 618
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

3-bromo-5-phenyl Salicylic Acid

C4516-25 25 mg
EUR 1292
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

3-bromo-5-phenyl Salicylic Acid

C4516-5 5 mg
EUR 370
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

5-bromo-3-phenyl Salicylic Acid

C4610-1 1 mg
EUR 109

5-bromo-3-phenyl Salicylic Acid

C4610-10 10 mg
EUR 528

5-bromo-3-phenyl Salicylic Acid

C4610-25 25 mg
EUR 1098
The most deleterious solvent, iso-propanol, not solely decreased the enthalpic contribution to binding however rendered the entropic contribution extra favorable. This method nonetheless doesn’t enable the relative significance of hydrogen bonding and van der Waals contacts within the precise binding to be differentiated but it surely does give indications on how a organic atmosphere could have an effect on a steroid-protein binding response in vivo.